A Trial of Tolerogenic Immunosuppression in Highly Sensitized Renal Transplant Recipients

Completed

Conditions studied: Kidney Diseases

In brief

Comparison between Campath induction and monotherapy with Tacrolimus vs Thymoglobulin induction and triple drug maintenance using Tacrolimus, mycophenolate, and steroids.

Key facts

Study ID

NCT00407160

Run by

The University of Texas Medical Branch, Galveston

People needed

21

Starts

2004-08-01

Expected to finish

2011-01-01

Last updated by the study team

2019-03-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females aged 18-75 years.
• Recipients of multiple kidney transplants
• Patients with a PRA >14% and/or a past historical PRA greater or equal to 50%.
• Females of childbearing potential must have a negative pregnancy test prior to inclusion.
• Patients who are willing and able to participate in the full course of the study and from whom written informed consent has been obtained.

You may not qualify if…

• Patients with a history of malignancy within the last 5 years, except excised squamous or basal cell carcinoma of the skin.
• Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after contraception and until the termination of gestation,confirmed by a positive human chorionic gonadotropin(hCG) laboratory test.
• Patients who are HIV positive.
• Patients with symptoms of significant somatic or mental illness or evidence of current drug and/or alcohol abuse.

Where it is running

• University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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