Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus
Completed
Conditions studied: Atopic Dermatitis
In brief
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Recent studies have demonstrated that the skin of people with AD my have decreased antimicrobial peptide (AMP) expression. The purpose of this study is to compare smallpox virus replication and the number of AMPs and other antiviral molecules in people with AD, as compared to those seen in people with psoriasis or asthma, or healthy individuals.
Key facts
- Study ID
- NCT00407069
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 286
- Starts
- 2005-06-01
- Expected to finish
- 2010-02-01
- Last updated by the study team
- 2016-10-18
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Oral corticosteroids or any systemic immunosuppressive or immunomodulatory medication within 28 days prior to study entry
- Immunotherapy within 3 months prior to study entry
- History of bleeding disorder
- Aspirin, oral antihistamines, oral antibiotics, oral cyclosporine, or topical medications within 7 days of screening visit including, but not restricted to, Protopic, Elidel, topical corticosteroids, and topical antibiotics
- Anxiolytic agents and antidepressants within 2 days of screening visit
- Diabetic requiring medication
- Autoimmune or immunodeficiency
- Active fungal, bacterial, or viral infections within 7 days prior to study entry
- Active systemic cancer. Participants with uncomplicated nonmelanoma skin cancer are not excluded.
- Theophylline or leukotriene antagonists within 24 hours of screening visit
- Received any vaccination within 30 days prior to study entry
- Known lidocaine allergy
- Previously vaccinated for smallpox
- Pregnant or breastfeeding
Where it is running
- National Jewish Health — Denver, Colorado, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.