Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.

Completed

Conditions studied: Circulatory Arrest

In brief

Primary Objective: The aim of this study is to assess the effects of Aprotinin (an antifibrinolytic drug used to reduce bleeding during cardiac surgery) on renal function in patients undergoing surgery with use of hypothermic bypass and circulatory arrest for repair of the thoracic aorta. Secondary Objective: To compare the effects of Aprotinin and Amicar on major vascular outcomes following thoracic aorta surgery with use of hypothermic bypass and circulatory arrest.

Key facts

Study ID

NCT00405093

Run by

Weill Medical College of Cornell University

People needed

1250

Starts

2006-07-01

Expected to finish

2013-05-01

Last updated by the study team

2017-01-19

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult male and female patients having surgery of ascending and aortic arch
• Use of Antifibrinolytic agents (Aprotinin and Aminocaproic Acid)

You may not qualify if…

• Emergency surgery for ruptured aorta
• Pre-Existing Renal Failure or Renal dysfunction (creatinine >2.0 mg/dl)
• Moderate or Severe Ventricular Dysfunction

Where it is running

• The New York Presbyterian Hospital - Weill Medical College of Cornell University — New York, New York, United States

Full record on ClinicalTrials.gov

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