Dichotic Listening as a Predictor of Medication Response in Depression
Completed · Phase 4
Conditions studied: Major Depressive Disorder, Dysthymia
In brief
This study will recruit 100 depressed patients to test whether the previous finding of an association between treatment response (with treatment groups including placebo, imipramine, and fluoxetine) and preferences of hemispheric laterality in perceptual processing are also found with a different type of commonly used anti-depressant, bupropion.
Key facts
- Study ID
- NCT00404755
- Run by
- New York State Psychiatric Institute
- People needed
- 17
- Starts
- 2006-07-01
- Expected to finish
- 2011-08-01
- Last updated by the study team
- 2018-04-30
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages between 18-65
- Meets Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) criteria for current Major Depression, Dysthymia or Depression Not Otherwise Specified
You may not qualify if…
- Known Hearing impairment
- Active suicidal ideation (history of suicide attempts will be evaluated on a case by case basis).
- Hamilton Rating Scale for Depression (HAMD), 21-item total score >20
- Current (past 6 months)alcohol and/or drug abuse or dependence
- Medical condition likely to require intervention contraindicated with study medication (e.g., known arrhythmia likely to be exacerbated by Imipramine)
- Bipolar I
- Psychosis
- Non-response to adequate trial of study medication (i.e., > or = 4 weeks on > or = bupropion 300mg/d, escitalopram 30mg/d, or imipramine 200mg/d)
- Premenopausal women not using known effective birth control
- Not currently depressed (whether considered due to current treatment or not)
- History of seizure, seizure disorder, anorexia nervosa, or bulimia
- Left-handed -
Where it is running
- New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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