Exercise Treatment of Mild-Stage Probable Alzheimer's Disease

Completed · Phase 2

Conditions studied: Alzheimer Disease, Memory Disorders, Dementia

In brief

The purpose of the study is to determine if participation in an exercise program helps memory loss from getting worse, and if it improves daily functioning and attitudes of those with probable Alzheimer's disease. It will involve participation of both the person with memory loss and someone who knows their daily activities (e.g., husband, wife, adult child, or caregiver).

Key facts

Study ID

NCT00403507

Run by

Intermountain Health Care, Inc.

People needed

79

Starts

2006-10-01

Expected to finish

2009-10-01

Last updated by the study team

2011-05-11

Who can join

Age: 65 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age is 65 through 89 years old.
• Completed more than an 8th grade education.
• Native English speaker.
• Diagnosis of probable Alzheimer's disease by a primary care physician or specialty clinic.
• Taking a cholinesterase inhibitor at a therapeutic dose for at least two weeks prior to admission to study (following minimum titration of four weeks), but no other prescribed medication for cognitive functioning (e.g., memantine/Namenda).
• May have one unstable physical illness that is being treated or a few controlled physical illnesses, is on few medications, and appears no more than mildly ill.
• Treated stable hypertension \& hyperlipidemia are permissible, but resting blood pressure must be <170/100 mm Hg.
• Normal TSH \& Vitamin B12 levels, as confirmed by laboratory data within 3 years.
• Able to participate a three-day/week physical activity program (No orthopedic, neurologic, or behavioral limitations that may preclude exercise training) for up to 6 months.
• Patient has a knowledgeable informant who can report the day-to-day activities of participant (e.g., spouse, adult child, paid caregiver).
• Able to give assent/consent to research study.

You may not qualify if…

• History of learning or developmental disability.
• Treatment with hormone replacement therapy during the last year.
• History of psychiatric condition (including depression).
• Evidence of serious cardiac condition or significant small vessel disease (e.g., heart bypass surgery, angina, arrhythmia, dyspnea, insulin-dependent diabetes with neuropathy, confluent white matter alterations on structural MRI or CT scan).
• History of neurologic condition (e.g., large vessel stroke, seizures, Parkinsonism).
• History of heavy metals exposure.
• History of sleep disturbance (e.g., treated apnea, insomnia).
• History of brain injury (including concussion of >10 minutes).
• History of delirium (change in mental status due to medications) for the past year.
• No pharmaceutical treatment for mood currently, or history of longstanding depression.

Where it is running

• LDS Hospital — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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