Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities
Completed · Phase 3
Conditions studied: PTSD
In brief
Dr. Wang's merit review is aimed at providing a better understanding of the relationship between SLC6A3/SLC6A4 and the mental health of veterans exposed to high levels of combat stress, specifically focusing on PTSD symptoms, related co-morbidities, treatment outcomes and seeks new approaches to therapy for our Veteran population.
Key facts
- Study ID
- NCT00403455
- Run by
- VA Office of Research and Development
- People needed
- 38
- Starts
- 2006-10-01
- Expected to finish
- 2011-07-01
- Last updated by the study team
- 2018-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male and female combat veterans ages 18 years and older who meet DSM-III-R criteria for principle diagnosis of PTSD as determined by the CAP-S;
- A minimum 6-month duration of PTSD illness; 3)CGI-S score of 4 or higher and a total CAPS-2 severity score of 50 or higher at the baseline visit;
- Homozygous for either the S/S or L/L 5-HTT;
- Females must not be pregnant or lactating and must agree to an acceptable form of contraception while receiving study medication and for 1 month after.
You may not qualify if…
- Presence of any other primary axis I disorder (concurrent depression will be permitted if it is judged to be secondary to development for PTSD);
- Suicide ideation or attempts within the past 3 months;
- Alcohol or substance abuse or dependence in the past six months;
- Evidence of clinically significant hepatic or renal disease;
- Previous seizure disorder or condition predisposing to seizures, or on medications that might lower the seizure threshold
- Any acute or unstable medical condition that might interfere with the safe conduct of the study;
- Intolerance or hypersensitivity to citalopram or any other SSRI;
- Treatment with a monoamine oxidase inhibitor within 14 days of initiating the study;
- Concomitant treatment with serotonin agonists, other SSRIs, meperidine, tramadol or other medication as determined by the study clinician.
- PTSD symptoms in need of immediate treatment as determined by clinical assessment from a psychiatrist not affiliated with the study.
Where it is running
- Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.