Effect of High-Dose B-Complex Vitamins on the Symptoms of Schizophrenia

Completed · Not applicable · Has a placebo group

Conditions studied: Schizophrenia, Schizoaffective Disorder

In brief

The purpose of this study is to determine whether individuals with schizophrenia who will take a high dose of the B-vitamins folate, B12 and pyridoxine, may experience improvement in their symptoms.

Key facts

Study ID

NCT00403247

Run by

Nathan Kline Institute for Psychiatric Research

People needed

50

Starts

2004-07-01

Expected to finish

2007-07-01

Last updated by the study team

2007-08-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of Schizophrenia or Schizoaffective Disorder
• Ages 18-65, male or female
• Treatment regimen includes a new-generation antipsychotic (clozapine, olanzapine,risperidone, quetiapine, ziprasidone or aripiprazole)
• Stable medication for 4 weeks prior to screening visit

You may not qualify if…

• Diagnosis of active substance use disorder within the last month
• Already taking vitamin supplements totaling > 400 mcg folic acid per day, or regular B12 injections
• Pregnant or breastfeeding
• Seizure disorder
• Non-English speaking
• Without capacity to give informed consent

Where it is running

• The Nathan Kline Institute for Psychiatric Research — Orangeburg, New York, United States

Full record on ClinicalTrials.gov

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