Treating the Endothelium to Restore Insulin Sensitivity

Completed · Not applicable

Conditions studied: Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes

In brief

A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.

Key facts

Study ID

NCT00402194

Run by

Indiana University

People needed

17

Starts

2005-06-01

Expected to finish

2012-03-01

Last updated by the study team

2013-09-24

Who can join

Age: 20 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Age 20-55
• Male and female
• Obese, defined as Males: BMI >28 or > 30% fat by DEXA scan or Bod Pod; Females: BMI >30 or > 33% fat by DEXA scan or Bod Pod
• Weight stable over at least 4 months

You may not qualify if…

• Diabetes mellitus (ADA criteria)
• Age <20 or > 55 yrs
• Blood pressure >160/90 or < 90/65 mmHg
• Total cholesterol >240 or LDL cholesterol >160 mg/dL
• Baseline elevations in AST or ALT > 3X ULN
• Baseline elevation in creatinine >1.6 ng/mL
• Unexplained baseline elevation in creatine kinase > 3X ULN
• Concurrent significant chronic medical illness including, but not limited to, human immunodeficiency virus infection, Syphilis, hepatitis B infection, or hepatitis C infection
• Pregnancy
• Known hypersensitivity or intolerance to the study agents

Where it is running

• Indiana University Hospital GCRC — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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