Bone Mineral Content and Bone Metabolism in Adolescents on Antipsychotic Therapy
Completed
Conditions studied: Adolescent Depression
In brief
We hypothesize that antipsychotic induced hyperprolactinemia can decrease bone mineral accrual and decrease bone mineral content (BMC) in adolescents on antipsychotic therapy. Specifics Aims 1. To determine if antipsychotic therapy leads to decreased bone mineral accrual and decreased bone mineral content in a group of adolescents on antipsychotic therapy by comparing them to an ethnicity, gender and pubertal stage matched control group. 2. To determine the relationship between serum concentrations of prolactin, sex steroids and bone turnover markers in adolescents on antipsychotic therapy and an ethnicity, gender and pubertal stage matched control group.
Key facts
- Study ID
- NCT00399776
- Run by
- Creighton University
- People needed
- 60
- Starts
- 2006-10-01
- Expected to finish
- 2009-09-01
- Last updated by the study team
- 2011-08-04
Who can join
Age: 10 and older, up to 17. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adolescent females and males with antipsychotic exposure equivalent to at least 100 chlorpromazine equivalents for a minimum of one year.
- Age between 10 and 17 years of age
- Within 10th and 90th percentile for height and weight -
You may not qualify if…
- Pregnant
- Chronic illness such as asthma, inflammatory bowel disease, rheumatoid disorders or cystic fibrosis.
- On chronic systemic steroid therapy for the past 12 months
- For subjects with hypothyroidism and on thyroid replacement therapy, TSH level will be obtained to determine eligibility.
- Menstrual irregularities secondary to excessive physical activity.
- History of anorexia nervosa and/or bulimia nervosa.
- Subjects on hormonal contraception. -
Where it is running
- Creighton University Psychiatry Research Center — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.