Immune Cell Response to Stimuli
Recruiting now
Conditions studied: Inflammation
In brief
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribute to inflammation, and will measure substances in the blood plasma (the liquid, non-cellular part of the blood) that might stimulate white blood cells, in order to understand how the blood responds to possible disease-related conditions. Healthy normal volunteers 18 years of age and older who weigh at least 110 pounds may be eligible for this study. Participants give about 320 milliliters (mL) of blood (about 1 1/3 cups) or less at each donation. They donate no more than once every 8 weeks and no more than six times a year. On some occasions, less than 320 mL of blood may be drawn. The collected blood is separated into its components and specific cells are exposed to substances to examine their response.
Key facts
- Study ID
- NCT00397280
- Run by
- National Institute of Environmental Health Sciences (NIEHS)
- People needed
- 750
- Starts
- 2009-07-13
- Last updated by the study team
- 2026-08-07
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- By questionnaire:
- Feeling ill within the last 24 hours.
- Alcohol consumption in the last 24 hours.
- Visit to the dentist in the last 24 hours.
- A doctor visit for illness or vaccination in the last 2 weeks.
- Diarrhea in the last 2 weeks.
- Recurrent fever (4 weeks).
- Pregnant or suspected pregnancy in the last 6 weeks.
- Blood or plasma donation that will cause the participant to exceed 550ml of blood in the last 8 weeks.
- Receiving a blood donation in the past 12 months.
- Bleeding disorder.
- Anemia.
- Heart problems.
- Insulin dependent diabetes.
- Problems with blood donation.
- Risk of or evidence of Creutzfeldt-Jacob Disease in the family.
- HIV-positive status, Hepatitis B/C-positive status or other confirmed or suspected immunosuppressive or immunodeficient conditions.
- Use of immunosuppressants or other immune-modifying drugs.
- Use of selected medications within the preceding 5 days unless the PI or AI receiving the samples states otherwise (NSAIDS/aspirin/tylenol, antidepressants, antihistamines , corticosteroids, HMG CoA reductase inhibitors, and antihypertensives).
- By exam:
- Temperature over 99.5 F.
- Blood pressure less than 90/50.
- Blood pressure higher than 170/95 mm Hg.
- Pulse rate less than 50 or greater than 100 beats/minute.
- If blood donation exceeds 200ml:
Where it is running
- NIEHS Clinical Research Unit (CRU) — Research Triangle Park, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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