Effects Of Darbepoetin On Vascular Repair Mechanisms In Kidney Disease The DARBEPC Study

Completed

Conditions studied: Chronic Kidney Disease, Anemia

In brief

Humans have cells in their blood stream called endothelial progenitor cells or EPCs. These are thought to be important in keeping blood vessels healthy. People with chronic kidney disease (CKD) have low numbers of these cells. People with cardiovascular (heart and blood vessel) disease also have low numbers. Patients with CKD have more cardiovascular disease then any other group.Erythropoietin is a hormone made by the kidneys. It is essential for making red blood cells and also activates EPCs. It is low in people with kidney disease. As part of your regular medical care for correcting your low red blood cell count, you will be receiving a medication that acts like erythropoietin. It is called darbepoetin. The purpose of this study is to see if darbepoetin treatment affects EPC numbers and function.

Key facts

Study ID

NCT00396123

Run by

University of Michigan

People needed

12

Starts

2006-11-01

Expected to finish

2008-07-25

Last updated by the study team

2017-06-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled in University of Michigan's Nephrology Anemia Clinic
• 18 years old or older
• Have kidney disease but are not on dialysis

You may not qualify if…

• Not enrolled in University of Michigan's Nephrology Anemia Clinic
• Less than 18 years of age
• Hematocrit that is less than 28.5%
• Currently participating in a clinical trial with an intervention
• Planning to change their tobacco use habits during the study period
• Have had dose changes of certain medications for cholesterol or diabetes within one month of study enrollment
• Are currently receiving:
• darbepoetin
• erythopoietin
• medications to lower your immune system
• Have had problems within the last 3 months with:
• Bleeding
• Heart attack or stroke
• Heart or blood vessel procedures
• Are pregnant or lactating

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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