Chemotherapy, Radiation Therapy and Immunotherapy Prior to Surgery in Operable Esophageal Cancer
Completed · Phase 2
Conditions studied: Esophageal Cancer
In brief
The purpose of this study is to see if adding two targeted drugs (bevacizumab and erlotinib) further improves the response to chemotherapy (5-FU, paclitaxel, carboplatin) and radiation therapy in patients with operable esophageal cancer. Side effects (toxicity) information will also be collected.
Key facts
- Study ID
- NCT00393068
- Run by
- SCRI Development Innovations, LLC
- People needed
- 62
- Starts
- 2007-02-01
- Expected to finish
- 2011-08-01
- Last updated by the study team
- 2022-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinically confirmed esophageal or gastroesophageal junction cancer stage I, II or III
- No prior treatment for esophageal cancer
- Must be surgical candidate based on stage and location of disease
- Measurable or evaluable disease
- Able to be up and perform self care
- Adequate liver, renal function and bone marrow function
- Patients will have to have a central venous access device placed
- Able to give written informed consent.
- Age 18 or older
You may not qualify if…
- Stage IV disease
- Prior cancer treatment for advanced cancer in the last 5 years
- Pregnant or lactating women
- History of stroke, transient ischemic attacks, or acute MI within the past 6 months or any other serious cardiovascular disease
- History of neurological disease
- Recent history of blood in the sputum or vomitus
- Non-healing wounds, ulcer or long bone fractures
- History of bleeding problems or coagulation problems
- History of abdominal fistula, gi perforation or intrabdominal abscess within 6 months
- History of uncontrolled hypertension
- Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have. You can then decide if you wish to participate.
Where it is running
- Florida Cancer Specialists — Fort Myers, Florida, United States
- Integrated Community Oncology Network — Jacksonville, Florida, United States
- Northeast Georgia Medical Center — Gainesville, Georgia, United States
- Consultants in Blood Disorders and Cancer — Louisville, Kentucky, United States
- Hematology Oncology Associates of Northern NJ — Morristown, New Jersey, United States
- Aultman Hospital — Canton, Ohio, United States
- Oncology Hematology Care — Cincinnati, Ohio, United States
- Chattanooga Oncology Hematology Associates — Chattanooga, Tennessee, United States
- Tennessee Oncology, PLLC — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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