Xylitol Adult Caries Trial (X-ACT)

Completed · Phase 3 · Has a placebo group

Conditions studied: Dental Caries

In brief

The purpose of the trial is to determine the extent to which daily use of xylitol lozenges reduces the appearance of new caries lesions in adults who tend to experience such lesions (i.e., caries-active adults).

Key facts

Study ID

NCT00393055

Run by

University of North Carolina, Chapel Hill

People needed

709

Starts

2007-01-01

Expected to finish

2011-06-01

Last updated by the study team

2011-09-12

Who can join

Age: 25 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 25-80
• at least one caries lesion in year prior to enrollment
• at least 12 teeth without crowns
• no allergies to xylitol or aspartame
• anticipate remaining in area for 3 years

You may not qualify if…

• 10 or more caries lesions in year prior to enrollment
• currently receiving long-term antibiotic therapy
• history of head and neck radiation

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of North Carolina School of Dentistry — Chapel Hill, North Carolina, United States
• University of Texas Health Science Center — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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