Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors

Status unconfirmed · Phase 3

Conditions studied: Brain and Central Nervous System Tumors

In brief

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. A bone marrow or peripheral stem cell transplant using stem cells from the patient may be able to replace blood-forming cells that were destroyed by chemotherapy. This may allow more chemotherapy to be given so that more tumor cells are killed. PURPOSE: This phase III trial is studying how well giving combination chemotherapy with or without etoposide followed by an autologous stem cell transplant works in treating young patients with previously untreated malignant brain tumors.

Key facts

Study ID

NCT00392886

Run by

Children's Hospital Los Angeles

People needed

120

Starts

2004-03-01

Last updated by the study team

2013-12-18

Who can join

Age: any, up to 10. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital Outpatient Center — Phoenix, Arizona, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Mattel Children's Hospital at UCLA — Los Angeles, California, United States
• Children's Hospital and Research Center Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
• University of Chicago Comer Children's Hospital — Chicago, Illinois, United States
• Riley's Children Cancer Center at Riley Hospital for Children — Indianapolis, Indiana, United States
• Kosair Children's Hospital — Louisville, Kentucky, United States
• Helen DeVos Children's Hospital at Spectrum Health — Grand Rapids, Michigan, United States
• Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Tomorrows Children's Institute at Hackensack University Medical Center — Hackensack, New Jersey, United States
• Schneider Children's Hospital — New Hyde Park, New York, United States
• NYU Cancer Institute at New York University Medical Center — New York, New York, United States
• Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
• SUNY Upstate Medical University Hospital — Syracuse, New York, United States
• Albert Einstein Cancer Center at Albert Einstein College of Medicine — The Bronx, New York, United States
• Rainbow Babies and Children's Hospital — Cleveland, Ohio, United States
• Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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