Investigating the Regulation of Reproductive Hormones in Adult Men
Completed · Not applicable
Conditions studied: Kallmann Syndrome, Hypogonadism, Gonadal Disorder
In brief
The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. We would like to understand what role testosterone and estradiol play in controlling the release of LH (lutenizing hormone) and FSH (follicle stimulating hormone). Testosterone and estradiol come from the testes, and LH and FSH are released from a gland in the head called the pituitary. Men involved in the study will have detailed evaluations that involve overnight stays in the hospital and frequent blood sampling. The men in the study will also be receiving medications that affect the levels of various hormones in the body. This will allow the researchers to learn how various hormones influence each other. Men that participate in the study will receive medical evaluations and monetary compensation. Information gathered from this study will help in the development of new treatments for infertility and potentially new hormonal forms of contraception.
Key facts
- Study ID
- NCT00392457
- Run by
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- People needed
- 175
- Starts
- 1995-07-01
- Expected to finish
- 2007-02-01
- Last updated by the study team
- 2015-02-16
Who can join
Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Men aged 18 to 50 years
- In good health
- On no medications
You may not qualify if…
- Subjects will not be enrolled in this study if there is a history of:
- Liver disease or if screening blood tests demonstrate abnormal liver function tests
- Excessive alcohol consumption
- Illicit drug use
- Severe drug allergy
- Use of any concomitant medications
- Peptic ulcer disease or gastritis
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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