Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

Completed · Phase 4

Conditions studied: Cataract

In brief

Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.

Key facts

Study ID

NCT00392275

Run by

Indiana University

People needed

48

Starts

2002-11-01

Expected to finish

2006-05-01

Last updated by the study team

2013-04-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients with functioning filtering blebs will be evaluated prospectively for inclusion

You may not qualify if…

• Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following exclusion criteria:
• Ongoing ocular inflammatory disease
• Bleb leakage - determined by Seidel test
• Suspected infection
• Known contraindications to use of any of these study medications.
• Pregnancy

Where it is running

• Indiana University Hospital — Indianapolis, Indiana, United States
• Richard L Rodeboush VA Medical Center — Indianapolis, Indiana, United States
• Wishard Memorial Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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