A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

Completed · Phase 3

Conditions studied: Acute Coronary Syndrome

In brief

Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.

Key facts

Study ID

NCT00391872

Run by

AstraZeneca

People needed

18624

Starts

2006-10-01

Expected to finish

2009-03-01

Last updated by the study team

2012-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female 18 years or older who has been hospitalised for chest pain and potential ACS
• Females of child-bearing potential must have a negative pregnancy test at enrollment and be willing to use 2 methods of reliable contraception

You may not qualify if…

• Persons with moderate or severe liver disease
• Persons who have already been treated with an invasive (angioplasty) procedure for the current episode of ACS
• Persons who are being treated with blood clotting agents that cannot be stopped

Where it is running

• Research Site — Huntsville, Alabama, United States
• Research Site — Mobile, Alabama, United States
• Research Site — Tucson, Arizona, United States
• Research Site — Bakersfield, California, United States
• Research Site — Beverly Hills, California, United States
• Research Site — Burbank, California, United States
• Research Site — Healdsburg, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Roseville, California, United States
• Research Site — Sacramento, California, United States
• Research Site — San Diego, California, United States
• Research Site — Torrance, California, United States
• Research Site — Fort Collins, Colorado, United States
• Research Site — Danbury, Connecticut, United States
• Research Site — Hartford, Connecticut, United States
• Research Site — Newark, Delaware, United States
• Research Site — Washington D.C., District of Columbia, United States
• Research Site — Atlantis, Florida, United States
• Research Site — Daytona Beach, Florida, United States
• Research Site — Fort Lauderdale, Florida, United States
• Research Site — Hollywood, Florida, United States
• Research Site — Jacksonville, Florida, United States
• Research Site — Jupiter, Florida, United States
• Research Site — Melbourne, Florida, United States
• Research Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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