Identifying Genetic Causes of IC/BPS

Recruiting now

Conditions studied: Interstitial Cystitis, Bladder Pain Syndrome

In brief

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, the investigators are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. The investigators are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.

Key facts

Study ID

NCT00389142

Run by

Boston Children's Hospital

People needed

1000

Starts

2006-01-15

Expected to finish

2030-12-31

Last updated by the study team

2025-12-16

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of IC/BPS
• Males and females of any age
• Urinary frequency - more than 1X/hour, and/or
• Dysuria, and/or
• Pelvic, suprapubic, or abdominal pain - for 3 months or longer
• Nocturia
• Normal urinary stream (by history)
• No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
• First degree relative of someone with above symptoms

You may not qualify if…

• Major structural/anatomical urinary tract abnormalities by ultrasound
• Underlying inborn conditions affecting the urinary tract
• Surgery/chemotherapy affected pelvic area
• GI or GU cancers
• Severe Constipation in children only

Where it is running

• Boston Children's Hospital (BCH) — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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