A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease

Status unconfirmed · Phase 2

Conditions studied: Parkinson Disease

In brief

This study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, \[123I\]β-CIT , in a population of first-degree relatives of PD patients as a tool to establish an 'at risk' Parkinson disease cohort without motor symptoms of PD. First-degree relatives of PD will be recruited through PD research sites and national foundations to participate in this study. In addition, first degree relatives of PD patients will be recruited directly through advertising.

Key facts

Study ID

NCT00387075

Run by

Institute for Neurodegenerative Disorders

People needed

3000

Starts

2006-11-01

Expected to finish

2023-08-01

Last updated by the study team

2022-03-29

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• diagnosis of PD or other neurodegenerative disorder
• other known reason for abnormal olfaction (e.g. nasal trauma, sinus infection, sinus surgery)
• pregnancy, if participating in the imaging portion of this study

Where it is running

• Institute for Neurodegenerative Disorders — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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