Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)

Completed · Phase 4

Conditions studied: Post Operative Pain

In brief

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied. The study proposes to treat the patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Key facts

Study ID

NCT00385541

Run by

Columbia University

People needed

50

Starts

2003-11-01

Expected to finish

2007-10-01

Last updated by the study team

2018-08-14

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients scheduled for abdominal surgery requiring post-operative PCA
• ASA = I or II

You may not qualify if…

• preoperative pain or use of pain medication
• narcotic allergy
• morbid obesity (Body Mass Index > 30)
• diagnosis of sleep apnea
• hepatic or renal disease
• use of medications that would affect narcotic pharmacodynamics
• preoperative nausea, vomiting, or pruritis
• diagnosis of alcoholism

Where it is running

• Columbia Presbyterian Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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