Endothelial Dysfunction As A Predictor Of Perioperative Outcome

Completed

Conditions studied: Endothelial Dysfunction

In brief

The goal of this clinical research study is to learn whether the inability of certain blood vessel cells (endothelial cells) to function properly may help researchers to predict who is at risk for complications after surgery and whether this dysfunction contributes to complications after surgery. This study will use a blood test to quantify the number of cells that are destined to become endothelial cells.

Key facts

Study ID

NCT00384683

Run by

M.D. Anderson Cancer Center

People needed

90

Starts

2006-03-01

Expected to finish

2019-06-05

Last updated by the study team

2019-09-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients scheduled for major thoracic surgery (lobectomy, pneumonectomy, esophagectomy).
• Patients 18 years of age or older.
• Patients who have signed the consent form to participate in the study.
• Patients must have been evaluated in the Preanesthesia Clinic or by a staff Anesthesiologist preoperatively.
• All laboratory and diagnostic evaluations required or used to evaluate the patient in the Preanesthesia Clinic must be completed. All patients must be approved for surgery by the standards of the Preanesthesia Clinic.

You may not qualify if…

• Refusal to participate in the study.
• Patient is under age 18.
• Patient is unwilling to sign consent.
• Patient is unable to exercise (bedridden or wheel chair bound).
• Patient is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
• Any patient whose condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
• Surgery canceled for any reason. The patient may reenter the study if surgery is rescheduled.
• Patient has had a myocardial infarction within 3 months of visiting the Preanesthesia Clinic or presents with new or unstable angina.
• Patient has a history of cerebrovascular accident or transient ischemic attacks within 3 months of visiting the Preanesthesia Clinic.
• Patient has a history of pulmonary embolic event within 3 months of visiting the Preanesthesia Clinic.
• Patient known to have acute or chronic deep vein thrombosis.
• Pregnant patients.

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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