First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX

Completed · Phase 2/Phase 3

Conditions studied: Colorectal Cancer

In brief

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab) in combination with FOLFOX.

Key facts

Study ID

NCT00384176

Run by

AstraZeneca

People needed

1814

Starts

2006-08-30

Expected to finish

2015-08-19

Last updated by the study team

2017-04-14

Who can join

Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical Diagnosis of colon or rectal cancer
• No prior systemic therapy for metastatic disease. Any adjuvant/neoadjuvant oxaliplatin therapy must have been received >12 months prior to study entry and adjuvant/neoadjuvant 5-FU must have been received >6 months prior to study entry.

You may not qualify if…

• Prior treatment with a VEGF Inhibitor, including bevacizumab and cediranib.
• Poorly controlled hypertension

Where it is running

• Research Site — Birmingham, Alabama, United States
• Research Site — Casa Grande, Arizona, United States
• Research Site — Tucson, Arizona, United States
• Research Site — Hot Springs, Arkansas, United States
• Research Site — Palm Springs, California, United States
• Research Site — San Diego, California, United States
• Research Site — Fairfield, Connecticut, United States
• Research Site — Stamford, Connecticut, United States
• Research Site — Bay Pines, Florida, United States
• Research Site — Fort Meyers, Florida, United States
• Research Site — Port Saint Lucie, Florida, United States
• Research Site — Galesburg, Illinois, United States
• Research Site — Park Ridge, Illinois, United States
• Research Site — Quincy, Illinois, United States
• Research Site — Layfayette, Indiana, United States
• Research Site — New Albany, Indiana, United States
• Research Site — Alexandria, Louisiana, United States
• Research Site — Layfayette, Louisiana, United States
• Research Site — Hagerstown, Maryland, United States
• Research Site — Ann Arbor, Michigan, United States
• Research Site — Ypsilanti, Michigan, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Great Falls, Montana, United States
• Research Site — Lincoln, Nebraska, United States
• Research Site — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.