Pemetrexed and Gemcitabine Every 14 Days Versus Every 21 Days in Advanced Non Small Cell Lung Cancer
Stopped early · Phase 2
Conditions studied: Non-Small-Cell Lung Cancer
In brief
This study is designed to evaluate Pemetrexed and Gemcitabine Day 1 followed by Gemcitabine Day 8 every 21 days (Arm A) and Pemetrexed and Gemcitabine Day 1 every 14 days (Arm B) in patients with NSCLC. Each agent and sequence has well demonstrated antitumor activity respectively in patients with locally advanced or metastatic NSCLC. Therefore, it is reasonable to investigate the most optimal schedule for this combination, and which combination is associated with the most anti-tumor activity in the phase II arena.
Key facts
- Study ID
- NCT00383331
- Run by
- Eli Lilly and Company
- People needed
- 19
- Starts
- 2007-02-01
- Expected to finish
- 2008-01-01
- Last updated by the study team
- 2009-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- histologic or cytologic diagnosis of NSCLC Stage IIIB or IV
- no prior systemic chemotherapy for advanced Non-Small Cell Lung Cancer
- Prior radiotherapy must be completed at least 4 weeks before study enrollment.
You may not qualify if…
- estimated life expectancy of 12 weeks
- a serious cardiac condition, such as myocardial infarction within 6 months, angina, or heart disease
- documented brain metastases unless the patient has completed successful local therapy for central nervous system metastases and has been off of corticosteroids for at least 2 weeks before enrollment
- significant weight loss (that is, > 10%) over the previous 6 weeks before study entry.
Where it is running
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.