Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder

Completed

Conditions studied: Schizophrenia, Bipolar Disorder

In brief

This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness.

Key facts

Study ID

NCT00382915

Run by

University of Medicine and Dentistry of New Jersey

People needed

276

Starts

2006-10-01

Expected to finish

2010-12-01

Last updated by the study team

2013-05-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For smokers with schizophrenia or bipolar disorder:
• Meets DSM-IV diagnostic criteria for schizophrenia or bipolar I disorder
• Smokes 10 or more cigarettes every day
• Has been stable on current psychiatric medications for at least 1 month prior to study entry
• For control smokers without mental illness:
• Smokes 10 or more cigarettes every day

You may not qualify if…

• For smokers with schizophrenia or bipolar disorder:
• Current or past suicidal ideation, behavior, or suicide attempt within 30 days prior to study entry
• Psychiatric hospitalization within 30 days prior to study entry
• Inability to read English or inability to sufficiently understand study documents written in English
• Pregnant, breastfeeding, or plans to become pregnant within 1 month of study entry
• Current use of any non-cigarette forms of tobacco (e.g., cigars, pipes, smokeless tobacco, or ultralight cigarettes)
• Current substance abuse problem, as defined by DAST or AUDIT criteria
• Significant cognitive impairment that may interfere with study participation, as defined by a Folstein Mini-Mental Status exam score of less than 22
• For control smokers without mental illness:
• Any DSM-defined mental disorder within 1 year prior to study entry
• Inability to read English or inability to sufficiently understand study documents written in English
• Concomitant use of nicotine replacement therapy (e.g., gum, patch, inhaler, nasal spray, or lozenge), clonidine, bupropion, or nortriptyline
• Pregnant, breastfeeding, or plans to become pregnant within 1 month of study entry
• Current use of any non-cigarette forms of tobacco (e.g., cigars, pipes, smokeless tobacco, or ultralight cigarettes)
• Diagnosis or treatment for an episode of any mental disorder (e.g., depression or anxiety) within 1 year prior to study entry
• Lifetime diagnosis of bipolar disorder or schizophrenia
• Lifetime history of any psychotic symptoms
• Lifetime use of antipsychotic medication for any reason
• Use of any antidepressants, mood stabilizers, or anti-anxiety medications for any reason within 6 months prior to study entry
• Current substance abuse problem, as defined by DAST or AUDIT criteria

Where it is running

• UMDNJ-Robert Wood Johnson Medical School, Department of Psychiatry, Division of Addictions — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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