Mitochondrial Dysfunction in Type 2 Diabetes Mellitus and Capacity for Fat Oxidation During Exercise
Stopped early · Not applicable
Conditions studied: Diabetes Mellitus, Type 2, Overweight
In brief
The purpose of this study is to compare the effects of an 8-week aerobic training program upon fat oxidation in vivo and markers of skeletal muscle mitochondrial content and oxidative capacity in sedentary obese subjects with and without type 2 diabetes. We will also investigate if mitochondrial content in muscle predicts success of weight loss. The specific aims are: * To compare systemic fat oxidation rates; * To measure mitochondrial content in muscle before and after aerobic training; * To determine if decreased mitochondrial content is also associated with decreased mitochondrial oxidative capacity; * To measure non-plasma fatty acid oxidation in vivo during submaximal exercise conditions both prior and after aerobic training; * To determine whether increases in fat oxidation due to physical activity predict weight loss success when a reduced calorie diet is added to a physical activity program.
Key facts
- Study ID
- NCT00382473
- Run by
- University of Pittsburgh
- People needed
- 29
- Starts
- 2006-09-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2014-04-25
Who can join
Age: 28 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women, aged 28-55 year-old, in general good health and with no contraindications to exercise. We are recruiting three groups of subjects: Group 1: overweight/obese adults with type 2 diabetes, with a BMI between 28-40. Group 2: overweight/obese adults without type 2 diabetes, with a BMI between 28-40. Group 3: adults without type 2 diabetes, with a BMI equal or less than 25 (not overweight/obese.)
You may not qualify if…
- Any condition that does not permit exercise; current participation in a regular physical activity; uncontrolled blood pressure; treatment with any of the following medications: insulin, any weight-loss drug, oral glucocorticoids, or any drugs that affect muscle and fat metabolism such as niacin, fibrates, and beta blockers
Where it is running
- University of Pittsburgh, Montefiore Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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