Intensive Diet and Exercise for Improving Knee Osteoarthritis in Obese and Overweight Older Adults

Completed · Not applicable

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to compare the effects of a calorie-restricting diet, exercise, and a combination of both in reducing knee inflammation and compressive forces in obese and overweight adults with knee osteoarthritis (OA).

Key facts

Study ID

NCT00381290

Run by

Wake Forest University

People needed

454

Starts

2006-10-01

Expected to finish

2011-06-01

Last updated by the study team

2017-11-06

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Grade II to III radiographic tibiofemoral OA of one or both knees
• Body mass index (BMI) of 27 to 37
• Sedentary lifestyle, defined as not participating in more than 30 minutes of formal exercise per week within the 6 months prior to study entry

You may not qualify if…

• Significant comorbidity that may pose a safety risk to the participant or otherwise interfere with the study. More information about this criterion can be found in the protocol.
• Previous acute knee injury
• Knee injection within 1 month of study entry
• Knee surgery within 6 months of study entry
• Knee OA other than tibiofemoral OA
• Unwilling or unable to change eating and physical activity habits due to environment
• Cannot speak or read English
• Excess alcohol use (21 or more drinks per week)
• Unable to finish the 18-month study or unlikely to comply with the study
• Unable to undergo MRI of the knee
• Significant cognitive impairment

Where it is running

• Wake Forest University/Wake Forest University Forest School of Medicine — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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