This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque.

Completed · Phase 4

Conditions studied: Coronary Arteriosclerosis

In brief

This study was designed to assess the effects on coronary artery plaque using aggressive lipid-lowering therapy versus moderate lipid-lowering therapy. A substudy will examine the effect of these treatments on brachial artery vasoactivity.

Key facts

Study ID

NCT00380939

Run by

Pfizer

People needed

600

Starts

1999-04-01

Expected to finish

2000-12-01

Last updated by the study team

2006-12-04

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Angiographic evidence of coronary artery disease as defined by a lesion that has at least 20% reduction in luman diameter by visual (angiographic) estimation in any native coronary artery. LDL cholesterol equal to 125mg/dl - 210mg/dl.

You may not qualify if…

• Patients who are anticipated to undergo coronary bypass surgery or cardiac transplantation during the course of the study. Known major hematologic, neoplastic, metabolic, gastrointestinal or endocrine dysfunction.

Where it is running

• Pfizer Investigational Site — Little Rock, Arkansas, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — San Diego, California, United States
• Pfizer Investigational Site — Denver, Colorado, United States
• Pfizer Investigational Site — BLUE Island, Florida, United States
• Pfizer Investigational Site — Gainesville, Florida, United States
• Pfizer Investigational Site — Atlanta, Georgia, United States
• Pfizer Investigational Site — Chicago, Illinois, United States
• Pfizer Investigational Site — Shawnee Mission, Kansas, United States
• Pfizer Investigational Site — Louisville, Kentucky, United States
• Pfizer Investigational Site — Auburn, Maine, United States
• Pfizer Investigational Site — Boston, Massachusetts, United States
• Pfizer Investigational Site — Kalamazoo, Michigan, United States
• Pfizer Investigational Site — Royal Oak, Michigan, United States
• Pfizer Investigational Site — Saint Clair, Michigan, United States
• Pfizer Investigational Site — Rochester, Minnesota, United States
• Pfizer Investigational Site — Albany, New York, United States
• Pfizer Investigational Site — New York, New York, United States
• Pfizer Investigational Site — Williamsville, New York, United States
• Pfizer Investigational Site — Chapel Hill, North Carolina, United States
• Pfizer Investigational Site — Greensboro, North Carolina, United States
• Pfizer Investigational Site — Greenville, North Carolina, United States
• Pfizer Investigational Site — Winston-Salem, North Carolina, United States
• Pfizer Investigational Site — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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