An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia

Completed · Phase 3

Conditions studied: Hyponatremia

In brief

This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion. The population studied will include patients with euvolemic or hypervolemic hyponatremia.

Key facts

Study ID

NCT00379847

Run by

Cumberland Pharmaceuticals

People needed

251

Starts

2004-02-01

Expected to finish

2005-06-01

Last updated by the study team

2014-05-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Serum sodium levels less than or equal 130mEq/L
• Euvolemic or Hypervolemic hyponatremia

You may not qualify if…

• Clinical evidence of volume depletion or dehydration
• Untreated severe hypothyroidism, hyperthyroidism, or adrenal insufficiency
• Uncontrolled brady-or tachyarrhythmias requiring pacemaker placement or treatment

Where it is running

• Study site — Tuscon, Arizona, United States
• Study site — Denver, Colorado, United States
• Study site — Washington D.C., District of Columbia, United States
• Study site — Augusta, Georgia, United States
• Study site — Petoskey, Michigan, United States
• Study site — Cincinnati, Ohio, United States
• Study site — Columbia, South Carolina, United States
• Study site — Afula, Israel
• Study site — Ashkelon, Israel
• Study site — Hadera, Israel
• 2 Sites — Haifa, Israel
• Study site — Holon, Israel
• 2 Sites — Jerusalem, Israel
• Study site — Nahariya, Israel
• Study site — Rehovot, Israel
• 2 Sites — Safed, Israel
• Study site — Tel Aviv, Israel
• Study site — Ẕerifin, Israel
• Study site — Amanzimototi, South Africa
• Study site — Bellville, South Africa
• Study site — Bloemfontein, South Africa
• 2 Sites — Durban, South Africa
• 4 Sites — Johannesburg, South Africa
• Study site — Krugersdorp, South Africa
• Study site — Lyttelton, South Africa

Full record on ClinicalTrials.gov

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