Anti Ischemic Effects of Abciximab in Angioplasty and Stenting Patients
Completed
Conditions studied: Coronary Artery Disease
In brief
AIR STUDY TITLE: Anti-Ischemic effects of Abciximab(Reopro) PATIENT POPULATION: Patients undergoing PCI(an interventional procedure placing a small stent/metallic tube to keep a narrowed artery in your heart open) and either on a stable statin dose or not on a statin. Statin= cholesterol lowering drug(ie, lipitor, zocor). INTERVENTION: Heparin vs. heparin + abciximab during PCI PURPOSE: Measure the effects of abciximab on special healing blood stem cells (EPC's-Endothelial Progenitor Cells), on inflammation, on oxidative stress and on microvascular blood flow. PATIENT ASSESSMENT: 1. 50ccs blood draw on day 1(from sheath), day 2 ,day 7 and day 28. 2. Measurement of blood flow in selected suitable patients 3. 10 minute questionnaire before discharge and on visit on day 28.
Key facts
- Study ID
- NCT00379418
- Run by
- Emory University
- People needed
- 220
- Starts
- 2003-01-01
- Expected to finish
- 2009-12-01
- Last updated by the study team
- 2013-09-12
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Have either:
- clinical history of anginal symptoms or positive stress test or
- in stent restenosis
- Have an angiographic >70% coronary artery stenosis that will be treated with coronary angioplasty or stenting procedure
- For at least four weeks prior to the procedure have been on, no Hmgcoa- reductase inhibitor or a stable statin dose
- negative pregnancy test
- are able to give informed consent
You may not qualify if…
- Coronary intervention within four weeks prior to enrollment.
- Treatment with abciximab antagonist within four weeks.
- treatment with thrombolytic therapy within 48 hours
- MI within 2 months.
- recent infections
- general anesthesia within 3 months.
- renal failure
Where it is running
- Atlanta VA Medical Center — Atlanta, Georgia, United States
- Emory University Hospital — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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