REVEAL: Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction

Completed · Phase 2

Conditions studied: Acute ST Elevation Myocardial Infarction

In brief

The purpose of this study is to evaluate whether erythropoietin can help limit the damage to the heart in patients with acute heart attacks.

Key facts

Study ID

NCT00378352

Run by

National Institute on Aging (NIA)

People needed

223

Starts

2005-09-01

Expected to finish

2011-01-01

Last updated by the study team

2017-05-09

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Clinical indication for erythropoietin
• STEMI (ST-elevation myocardial infarction) due to occlusion of a branch vessel
• Any history of prior MI, PCI (Percutaneous coronary intervention), CABG (Coronary artery bypass graft), cardiomyopathy, myocarditis, or CHF (congestive heart failure)
• Hypersensitivity to human albumin, mammalian cell-derived products, or erythropoietin
• Hematocrit greater than 42% in men or greater than 40% in women at the time of study drug administration
• Uncontrolled hypertension at the time of study drug administration
• Cardiogenic shock
• Need for coronary surgical revascularization as determined at the time of the index coronary catheterization
• History of hypercoagulable disorder, thromboembolic event, or venous thrombosis
• History of stroke or TIA (transient ischemic attack)
• History of seizures
• Contraindication to MRI
• Pregnancy or nursing mother

Where it is running

• Washington Hospital Center — Washington D.C., District of Columbia, United States
• University of Miami, School of Medicine — Miami, Florida, United States
• Emory University Hospital — Atlanta, Georgia, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• William Beaumont Hospital — Royal Oak, Michigan, United States
• Mayo Clinic, Rochester — Rochester, Minnesota, United States
• New York Methodist Hospital — Brooklyn, New York, United States
• Cornell University — New York, New York, United States
• NY Presbyterian Hospital — New York, New York, United States
• Weill Medical College — New York, New York, United States
• Duke University — Durham, North Carolina, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Ohio State University Medical Center — Columbus, Ohio, United States
• Penn State Heart and Vascular Institute — Hershey, Pennsylvania, United States
• Nashville Cardiovascular Magnetic Resonance Institute — Brentwood, Tennessee, United States
• Virginia Commonwealth University Medical Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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