Acetaminophen (Tylenol) for Mood and Memory Changes Associated With Corticosteroid Therapy
Completed · Phase 4 · Has a placebo group
Conditions studied: Asthma, Rheumatic Disease
In brief
Studies in humans and animals support that stress and/or elevations in corticosteroids lead to changes in hippocampal structure and functioning. This is important as patients with major depression frequently have elevated cortisol, and millions of patients receive prescription corticosteroids (e.g. prednisone). Both depression and corticosteroid therapy are associated with memory impairment and hippocampal atrophy. Our research uses corticosteroid-treated patients to explore interventions that might protect the brain from the effects of stress or corticosteroids. We propose to give 30 corticosteroid-treated asthma patients acetaminophen or placebo. Between group differences in mood, memory and other neurocognitive measures will serve as outcome measures.
Key facts
- Study ID
- NCT00377364
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 30
- Starts
- 2006-11-01
- Expected to finish
- 2008-10-01
- Last updated by the study team
- 2016-05-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-65
- Scheduled to receive at least 20 mg/day of prednisone for at least 7 days
- Baseline Rey Auditory Verbal Learning Test (RAVLT) total score of ≥40
You may not qualify if…
- History of allergic reaction or other contraindication to acetaminophen therapy
- Acetaminophen use within 24 hours of study entry
- History of liver disease or alcohol use of greater than 3 drinks/day
- Severe or unstable medical condition (e.g., recent myocardial infarction,renal failure, diabetes with poor glycemic control)
- Pregnant or lactating female
- Patient has mental retardation, dementia, or other severe cognitive disorder
Where it is running
- UT Southwestern Medical Center at Dallas — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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