The Effectiveness of Lower Cyclosporine Doses for Psoriasis
Withdrawn before enrolling · Phase 2
Conditions studied: Psoriasis
In brief
This study will evaluate whether lower doses of cyclosporine can cause fewer side effects and still produce the same beneficial results that are seen with a standard cyclosporine dose regimen when treating individuals with moderate to severe psoriasis.
Key facts
- Study ID
- NCT00377325
- Run by
- University of Rochester
- People needed
- 0
- Starts
- 2007-06-01
- Expected to finish
- 2013-09-01
- Last updated by the study team
- 2014-11-21
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Good health
- Exception that has been resistant to psoralen and ultraviolet A radiation (PUVA), methotrexate, and retinoids
- Moderate to severe, stable plaque psoriasis
- Normal organ and marrow function
- HIV uninfected
You may not qualify if…
- Topical therapy within 4 weeks of study entry
- Use of systemic, intralesional, or phototherapy within 1 year of study entry
- Use of cyclosporine in the past or use of other immunosuppressive medication within 6 months of study entry
- Inability to be followed or monitored regularly on a weekly basis
- Poorly controlled hypertension
- Severe infection, internal malignancy, immunodeficiency, gout, or liver disease
- Received more than 1,000 treatments of ultraviolet A (UVA)
- History of allergic reaction attributed to compounds of similar chemical or biological composition to cyclosporine
- Uncontrolled active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia that would limit study participation
- Women of childbearing potential and men unwilling to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for the duration of the study
- Pregnant
Where it is running
- University of Rochester Department of Dermatology — Rochester, New York, United States
Full record on ClinicalTrials.gov
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