PRospective Evaluation Comparing Initiation of Warfarin StrategiEs (PRECISE): Pharmacogenetic-guided Versus Usual Care
Withdrawn before enrolling · Phase 4
Conditions studied: Blood Coagulation Disorders
In brief
Warfarin (also called Coumadin®) is an anticoagulant drug (blood thinner) given to patients to help prevent blood clots from forming or to help prevent the growth of an existing blood clot. The purpose of this study is to collect information on a possible method used to determine the best warfarin dose for people before they start warfarin. This study will focus on finding out if a person's stable dose can be better predicted by using a new approach (called "pharmacogenetic-guided dosing") compared to the current warfarin dosing method. The pharmacogenetic-guided dosing method (the new warfarin dosing method) will use a person's specific health and genetic information to calculate a patient's warfarin dose at the beginning of warfarin treatment. The hope is that through this research, we may someday be able to use an individual's genetic information to guide the selection of their specific warfarin dose at the beginning of treatment, leading to precise warfarin dosing and less need for the current trial and error process.
Key facts
- Study ID
- NCT00377143
- Run by
- University of Florida
- People needed
- 0
- Starts
- 2006-07-01
- Last updated by the study team
- 2012-02-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Newly initiating warfarin
You may not qualify if…
- Previous use of warfarin
- Cancer
- Hepatic Disease
- History of alcoholism
- Diarrheal illness
- Febrile Illness
- Blood dyscrasias
- Pregnancy
- Medical plan to hold warfarin administration before stable dose is achieved (ie. for surgical intervention)
- Dementia
- Active bleed
- Aneurysm
Where it is running
- Shands at the University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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