S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving rituximab together with combination chemotherapy and bortezomib may kill more cancer cells. Giving bortezomib as maintenance therapy may keep the cancer from progressing. PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy and bortezomib followed by bortezomib alone works in treating patients with newly diagnosed mantle cell lymphoma.
Key facts
- Study ID
- NCT00376961
- Run by
- SWOG Cancer Research Network
- People needed
- 68
- Starts
- 2006-08-01
- Expected to finish
- 2017-09-01
- Last updated by the study team
- 2017-11-06
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Providence Cancer Center — Anchorage, Alaska, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Broward General Medical Center Cancer Center — Fort Lauderdale, Florida, United States
- M.D. Anderson Cancer Center at Orlando — Orlando, Florida, United States
- Mountain States Tumor Institute at St. Luke's Regional Medical Center — Boise, Idaho, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Reid Hospital & Health Care Services — Richmond, Indiana, United States
- Cancer Center of Kansas, PA - Chanute — Chanute, Kansas, United States
- Cancer Center of Kansas, PA - Dodge City — Dodge City, Kansas, United States
- Cancer Center of Kansas, PA - El Dorado — El Dorado, Kansas, United States
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center — Kansas City, Kansas, United States
- Cancer Center of Kansas, PA - Kingman — Kingman, Kansas, United States
- Southwest Medical Center — Liberal, Kansas, United States
- Cancer Center of Kansas, PA - Newton — Newton, Kansas, United States
- Olathe Cancer Center — Olathe, Kansas, United States
- Cancer Center of Kansas, PA - Parsons — Parsons, Kansas, United States
- Cancer Center of Kansas, PA - Pratt — Pratt, Kansas, United States
- Cancer Center of Kansas, PA - Salina — Salina, Kansas, United States
- Tammy Walker Cancer Center at Salina Regional Health Center — Salina, Kansas, United States
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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