Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence

Completed · Not applicable

Conditions studied: Cocaine Dependence

In brief

The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse treatment. This study will also determine whether patients who do respond to treatment will experience a recovery of dopamine function. This study includes free brain imaging and behavioral intervention. Compensation provided for the brain scans.

Key facts

Study ID

NCT00376558

Run by

New York State Psychiatric Institute

People needed

50

Starts

2006-07-01

Expected to finish

2011-01-01

Last updated by the study team

2016-07-01

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males or females between 21 and 45 years old
• Fulfill DSMIV criteria for cocaine abuse or dependence
• Able to give informed consent and comply with study procedures
• Medically Healthy

You may not qualify if…

• Major DSM-IV Axis I disorder other than cocaine abuse or dependence. Subjects with a history of other psychostimulant abuse/dependence or compulsive gambling will be excluded.
• Current use of opiates, sedative-hypnotic, and/or cannabis more than twice a week (use less than twice a week is acceptable).
• Current use of psychotropic medication such as antipsychotics or antidepressants.
• Presence or positive history of severe medical or neurological illness (including epilepsy), or any cardiovascular disease, low hemoglobin (Hb < 14 gm/dL in males, Hb < 12 gm/dL in females), or SGOT or SGPT > 2-3 times normal. Chronic active hepatitis B or C will also be an exclusion criteria.
• Resting SBP >150, DBP > 90
• Pregnancy or lactation, lack of effective birth control during 15 days before the scans*
• Evidence /report of any heart abnormality during intake medical history, EKG or physical exam.
• Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by neuroradiologists: "Guide to MR procedures and metallic objects" Shellock, PhD, Lippincott Williams and Wilkins, NY 2001.
• Lifetime exposure to radiation in the workplace, or history of participation in nuclear medicine procedures, including research protocols **
• Positive Allen Test indicating lack of collateral blood flow to hand
• History of sensitivity to methylphenidate

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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