Study of Atorvastatin Versus Placebo to Reduce Cardiopulmonary Complications After Thoracic Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Thoracic Surgery

In brief

This study will compare atorvastatin (Lipitor) with a placebo (inactive pill) to see if this drug reduces heart rhythm abnormalities (arrhythmias) or lung inflammation after thoracic surgery. Preliminary results suggest that cholesterol lowering drugs (statins) may reduce problems after surgery such as arrhythmias or lung inflammation which may be serious. This study will be randomized and double blind, meaning that patients are placed in groups purely by chance, like flipping a coin. Neither the patient or doctor will know which group the patient is in.

Key facts

Study ID

NCT00375518

Run by

Memorial Sloan Kettering Cancer Center

People needed

162

Starts

2006-07-01

Expected to finish

2014-05-01

Last updated by the study team

2021-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients ≥ 18 yr. scheduled for anatomic lung resection (segmentectomy, lingulectomy, possible or definite lobectomy, bilobectomy, pneumonectomy or extrapleural pneumonectomy) with or without chest wall resection or limited resection
• Patients with regular cardiac rhythm
• Patients able to take oral capsules
• Patients capable of providing written, informed consent
• Patients without known hepatic or kidney disease

You may not qualify if…

• Patients already taking any statin, gemfibrozil (Lopid), or ezetimibe (Zetia)
• Hypersensitivity to atorvastatin
• Chronic atrial fibrillation
• Patients already taking class Ic or III antiarrhythmic drugs
• Known pregnancy a urine pregnancy test will be given to women of childbearing age
• Known history of active hepatic disease or known hepatic insufficiency
• Known history of active kidney disease or insufficiency

Where it is running

• Memorial Sloan-Kettering Cancer Center 1275 York Avenue — New York, New York, United States

Full record on ClinicalTrials.gov

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