Characteristics of Prader-Willi Syndrome and Early-onset Morbid Obesity

Completed

Conditions studied: Prader-Willi Syndrome, Obesity

In brief

Prader-Willi syndrome (PWS) is a rare genetic disorder that affects about 1 in 14,000 people in the United States. As the most commonly identified genetic cause of obesity, PWS is often confused with Early-onset Morbid Obesity (EMO). Individuals with EMO show some signs of PWS, but clinically do not have PWS. The purpose of this study is to evaluate the clinical features and genetic basis of PWS and EMO, and to determine how these conditions affect a person throughout a lifetime.

Key facts

Study ID

NCT00375089

Run by

University of Florida

People needed

392

Starts

2006-09-01

Expected to finish

2014-01-01

Last updated by the study team

2014-09-22

Who can join

Age: any, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals enrolling in the Prader-Willi syndrome group will have a confirmed diagnosis of Prader-Willi syndrome, as confirmed by molecular and cytogenetic testing
• Individuals enrolling in the Early-onset Morbid Obesity group will have a documented medical history of their weight exceeding 150% of the ideal body weight or a body mass index greater than 97% before the age of 4 years; they will also be under the age of 30 years.

You may not qualify if…

• Known genetic, chromosomal, or hormonal cause of cognitive impairment other than Prader-Willi syndrome

Where it is running

• University of California at Irvine — Orange, California, United States
• University of Florida — Gainesville, Florida, United States
• Kansas University Medical Center — Kansas City, Kansas, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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