Preventing Depression Recurrence in Diabetes

Completed · Phase 4

Conditions studied: Major Depression, Diabetes

In brief

To study the effectiveness of sertraline (Zoloft) in treating depression in adults with diabetes. The study will also determine whether depressed diabetic patients who have successfully responded to sertraline (Zoloft) are more likely to have depression recur if the sertraline (Zoloft) is discontinued.

Key facts

Study ID

NCT00374426

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

262

Starts

1998-03-01

Expected to finish

2004-10-01

Last updated by the study team

2010-03-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-80
• Type 1 or Type 2 Diabetes
• Screen positive for depression

You may not qualify if…

• Are pregnant or lactating
• Are known to be hypersensitive to the drug
• Have a recent history of myocardial infarction or unstable heart disease
• Have severe hepatic disease or renal impairment (serum creatinine > 3 mg/dl)
• The subset of patients with psychiatric disorders thought to affect management (e.g., schizophrenia, alcohol and drug dependence) will also be excluded from participation

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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