Effects of Aripiprazole on Cocaine Craving and Self-Administration
Completed · Phase 2 · Has a placebo group
Conditions studied: Cocaine Abuse
In brief
The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration, subjective effects and cravings compared to placebo.
Key facts
- Study ID
- NCT00373880
- Run by
- New York State Psychiatric Institute
- People needed
- 26
- Starts
- 2005-04-01
- Expected to finish
- 2008-09-01
- Last updated by the study team
- 2017-09-11
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Meets DSM-IV criteria for current cocaine abuse
- Average use of smoked cocaine is at least 2x/week for past 6 mos); currently spends at least $70 per week on cocaine
- Has patterns of smoked cocaine use in terms of frequency and amounts which parallel or exceed those administered in the study
- Age 21-45
- Able to give informed consent, and comply with study procedures
You may not qualify if…
- Current seizure disorder, heart disease or psychiatric disorders (other than cocaine dependence)
- Dependence on substances other than cocaine or nicotine
- Request for drug treatment
- Judged to be noncompliant with study protocol
- Current use of any medication that has the potential to interact with aripiprazole (i.e., seizure medications, anti-fungal medications, cardiac medications, or medication that produces drowsiness)
- Clinical laboratory tests outside normal limits that are clinically unacceptable to the study physician (BP > 140/90; BUN, creatinine, LFTs > 1.5 ULN; hematocrit < 34 for women, < 36 for men; pseudocholinesterase deficiency)
- Currently meeting DSM-IV criteria for all major psychiatric/psychotic disorders other than transient psychosis due to drug abuse
- Current parole or probation
- History of significant violent or suicidal behavior
Where it is running
- Irving Center for Clinical Research — New York, New York, United States
Full record on ClinicalTrials.gov
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