Study of How Low Blood Sugar Affects the Way Blood Vessels Work

Completed

Conditions studied: Hypoglycemia

In brief

Hypothesis: Low blood sugar (hypoglycemia) decreases function of the lining of the blood vessels in normal humans. This study is designed to explore how hypoglycemia affects the function of the blood vessel lining. This will be determined by measuring blood flow to the arm before and after occlusion of flow. Blood vessel function will be measured before induction of hypoglycemia, during insulin induced hypoglycemia, and after recovery from hypoglycemia. A second study will be done but without hypoglycemia.

Key facts

Study ID

NCT00373854

Run by

Ohio State University

People needed

13

Starts

2005-09-01

Expected to finish

2006-09-01

Last updated by the study team

2016-06-08

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-40 years
• BMI <27 kg/m2

You may not qualify if…

• Pregnancy
• Systolic blood pressure >140 mmHg
• Diastolic Blood pressure >90 mg/dl
• Spot daytime urine microalbumin concentration > 20 μg/mg creatinine
• Past or present history of chronic disease (e.g. cancer, hypertension, cardiovascular disease, chronic inflammatory disease) other than diabetes in type 1 diabetic subjects.
• Use of non prescription medications in the past 3 days
• Use of prescription medications in the past 2 weeks

Where it is running

• Ohio State University — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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