Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
Completed · Phase 1/Phase 2
Conditions studied: Leukemia
In brief
RATIONALE: Drugs used in chemotherapy, such as clofarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of clofarabine when given together with cytarabine and to see how well they work in treating young patients with refractory or relapsed acute myeloid leukemia or acute lymphoblastic leukemia. (Phase I closed to enrollment as of 09/16/09)
Key facts
- Study ID
- NCT00372619
- Run by
- Children's Oncology Group
- People needed
- 74
- Starts
- 2007-03-01
- Expected to finish
- 2012-08-01
- Last updated by the study team
- 2017-06-05
Who can join
Age: 1 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Southern California Permanente Medical Group — Downey, California, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Rady Children's Hospital - San Diego — San Diego, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Children's Hospital Colorado Center for Cancer and Blood Disorders — Aurora, Colorado, United States
- Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- Nemours Children's Clinic - Orlando — Orlando, Florida, United States
- Nemours Children's Clinic - Pensacola — Pensacola, Florida, United States
- St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
- AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta, Georgia, United States
- Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- University of Illinois Cancer Center — Chicago, Illinois, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Simmons Cooper Cancer Institute — Springfield, Illinois, United States
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
- St. Vincent Indianapolis Hospital — Indianapolis, Indiana, United States
- Kosair Children's Hospital — Louisville, Kentucky, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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