Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia
Completed · Phase 3
Conditions studied: Leukemia
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as gemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving combination chemotherapy together with gemtuzumab may kill more cancer cells. It is not yet known whether combination chemotherapy is more effective with or without gemtuzumab in treating patients with newly diagnosed acute myeloid leukemia. PURPOSE: This randomized phase III trial is studying combination chemotherapy and gemtuzumab to see how well they work compared with combination chemotherapy alone in treating young patients with newly diagnosed acute myeloid leukemia.
Key facts
- Study ID
- NCT00372593
- Run by
- Children's Oncology Group
- People needed
- 1070
- Starts
- 2006-08-01
- Expected to finish
- 2020-09-30
- Last updated by the study team
- 2021-03-24
Who can join
Age: any, up to 29. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of South Alabama Mitchell Cancer Institute — Mobile, Alabama, United States
- Banner Desert Medical Center — Mesa, Arizona, United States
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Southern California Permanente Medical Group — Downey, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- Childrens Hospital Los Angeles — Los Angeles, California, United States
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
- Jonsson Comprehensive Cancer Center at UCLA — Los Angeles, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital and Research Center Oakland — Oakland, California, United States
- Kaiser Permanente Medical Center - Oakland — Oakland, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Rady Children's Hospital - San Diego — San Diego, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Santa Barbara Cottage Children's Hospital — Santa Barbara, California, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Torrance, California, United States
- Children's Hospital Center for Cancer and Blood Disorders — Aurora, Colorado, United States
- Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
- Yale Cancer Center — New Haven, Connecticut, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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