Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

Completed · Phase 3

Conditions studied: Periodontitis

In brief

The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease

Key facts

Study ID

NCT00371332

Run by

OraPharma

People needed

128

Starts

2004-01-01

Last updated by the study team

2006-09-25

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Generalized moderate to advanced chronic periodontitis, five sites with probing depths of >5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants

You may not qualify if…

• Allergy to tetracycline
• Subjects with aggressive periodontitis
• Acute necrotizing ulcerative gingivitis, or gross decay
• Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc)
• Individuals requiring prophylactic antibiotics
• Any periodontal therapy within the previous 3 months (excluding maintenance therapy)
• Systemic or local antibiotic therapy within three months

Where it is running

• Study site — Los Angeles, California, United States
• Study site — Baltimore, Maryland, United States
• Study site — Boston, Massachusetts, United States
• Study site — Buffalo, New York, United States
• Study site — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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