Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults
Completed · Not applicable
Conditions studied: Depression
In brief
This study will evaluate the efficacy of Problem Adaptation Therapy (PATH) vs. Supportive Therapy for Cognitively Impaired (ST-CI) older adults in reducing depression and disability in treating depressed, cognitively impaired older adults.
Key facts
- Study ID
- NCT00368940
- Run by
- Weill Medical College of Cornell University
- People needed
- 74
- Starts
- 2006-04-01
- Expected to finish
- 2011-09-01
- Last updated by the study team
- 2017-07-24
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meets Diagnostic and Statistical Manual for Mental Disorders(DSM)IV criteria for unipolar major depression
- Severity of depression greater than or equal to 17 on MADRS
- Disability as determined by at least 1 impairment in instrumental activities of daily living
- Evidence of executive dysfunction or impairment in at least one of the following cognitive domains of Dementia Rating Scale (DRS): attention, construction, conceptualization, and memory ([scaled score less than 7] adjusted for age and race based on Mayo's older participants normative data)
- Family member or caregiver able and willing to participate in treatment
- Not currently taking antidepressants, cholinesterase inhibitors, or memantine or on a stable dosage for 8 weeks prior to study entry with no medical recommendation for change of these agents in the near future
You may not qualify if…
- High suicide risk
- Axis I psychiatric disorder or substance abuse other than unipolar major depression or nonpsychotic depression
- Axis II diagnosis of antisocial personality
- Moderate to severe dementia: DRS total score corresponding to moderate or more severe impairment (scaled score less than or equal to 5)
- Acute or severe medical illness (e.g., delirium; metastatic cancer; decompensated cardiac; liver or kidney failure; major surgery; stroke; myocardial infarction during the 3 months prior to entry)
- Currently taking drugs known to cause depression (e.g., reserpine, alpha-methyl-dopa, steroids)
- Currently receiving psychotherapy
- Aphasia
- Sensory problems
- Inability to speak English
Where it is running
- Cornell Institute of Geriatric Psychiatry — White Plains, New York, United States
Full record on ClinicalTrials.gov
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