Study of Factors Involved in Resistance to Severe Malaria

Completed

Conditions studied: Malaria

In brief

This study will examine whether resistance to severe malaria is associated with weakening of a specific immune response (TLR-mediated pro-inflammatory cytokine response). Some children with mild malaria go on to develop severe disease, while others do not. The study will analyze certain substances in the blood to try to determine what factors may protect against severe malaria. Healthy children and children 3 - 10 years of age with severe malaria who are being treated at l'H pital Gabriel Toure in Mamako, Mali, West Africa, may be eligible for this study. Participants have a mall sample of blood drawn from a vein and from two finger pricks.

Key facts

Study ID
NCT00368810
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
People needed
120
Starts
2006-02-21
Expected to finish
2006-11-30
Last updated by the study team
2017-07-02

Who can join

Age: 2 and older, up to 10. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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