Sertraline Pharmacotherapy for Alcoholism Subtypes

Completed · Phase 4 · Has a placebo group

Conditions studied: Alcoholism

In brief

The purpose of this study is to determine whether Sertraline, compared to placebo, is effective in the treatment of alcohol dependence as a function of the subtype of alcoholic patient being treated. This involved administering sertraline (to a maximum of 200 mg/day) or an inactive placebo for a 14-week treatment period.

Key facts

Study ID

NCT00368550

Run by

UConn Health

People needed

134

Starts

2004-02-01

Expected to finish

2009-12-01

Last updated by the study team

2011-06-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current episode (i.e., in the preceding month) of alcohol dependence defined by Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV) criteria
• 18-65 years of age
• Abstinent from alcohol for a period of at least 3 days prior to baseline research assessment
• Able to read English and complete study evaluations
• Male, or if female, without active reproductive potential
• Participants will have signed informed consent

You may not qualify if…

• Currently meets criteria for dependence on a psychoactive substance other than alcohol and nicotine
• Regular use of psychoactive drugs including anxiolytics and antidepressants
• Current use of disulfiram or naltrexone
• Current major depression or psychosis (or other severe psychiatric disability e.g., suicidality, current mania)
• Significant underlying medical conditions such as hepatic, cerebral, renal, thyroid, or cardiac pathology, which in the opinion of the evaluating physician would preclude the patient from study adherence or be of potential harm to the subject

Where it is running

• University of Connecticut Health Center — Farmington, Connecticut, United States

Full record on ClinicalTrials.gov

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