Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals

Completed · Not applicable

Conditions studied: Cardiovascular Diseases, Obesity

In brief

Obese individuals are at risk for developing cardiovascular disease (CVD). Increasing physical activity, losing weight, and reducing sodium intake may reverse arterial stiffness and blood vessel damage that is linked to obesity. This study will evaluate the effectiveness of a low sodium diet and a behavioral weight loss intervention in reducing arterial stiffness in overweight young adults.

Key facts

Study ID

NCT00366990

Run by

University of Pittsburgh

People needed

349

Starts

2007-01-01

Expected to finish

2013-06-01

Last updated by the study team

2016-03-08

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index (BMI) between 25 and 35

You may not qualify if…

• High blood pressure currently being treated with medication
• Blood pressure greater than or equal to 140/90 mm Hg on two consecutive study visits
• Diabetes, defined as either a fasting glucose test result of .126 or current use of hypoglycemic medications
• Currently taking hyperlipidemia medication
• Currently taking vasoactive medications
• History of known atherosclerotic disease (e.g., angina, heart attack, lower extremity arterial disease)
• Underlying inflammatory condition (e.g., systemic lupus erythematosus, rheumatoid arthritis)
• Chronic infection
• Current participation in a formal exercise or weight loss program
• Pregnant or planning to become pregnant during the study

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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