Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in Patients With Non-Small Cell Lung Cancer

Stopped early · Phase 2

Conditions studied: Non-Small Cell Lung Carcinoma

In brief

The goals of this study are: * to determine if the combination of two drugs, motexafin gadolinium and pemetrexed, may be an effective treatment for patients with non-small cell lung cancer (NSCLC) who have had one previous chemotherapy regimen that included a platinum containing drug such as cisplatin or carboplatin. * to assess response to treatment in patients with NSCLC six months after beginning study treatment.

Key facts

Study ID

NCT00365183

Run by

Pharmacyclics LLC.

People needed

74

Starts

2006-06-01

Expected to finish

2008-06-01

Last updated by the study team

2013-10-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older
• Stage IIIb, metastatic, or recurrent NSCLC patients who have received one prior platinum-based chemotherapy regimen
• ECOG performance status score of 0 or 1

You may not qualify if…

• Laboratory values indicating inadequate function of bone marrow, liver, or kidneys
• Symptomatic or uncontrolled brain metastases
• Evidence of meningeal metastasis
• > 1 prior regimen (not counting adjuvant or neo-adjuvant cytotoxic chemotherapy if completed > 12 months prior to regiment)
• Medical condition that would increase risk if treated with motexafin gadolinium or impair ability to complete study procedures and assessments

Where it is running

• Study site — Huntington Beach, California, United States
• Study site — Long Beach, California, United States
• Study site — Chicago, Illinois, United States
• Study site — Baltimore, Maryland, United States
• Study site — Minneapolis, Minnesota, United States
• Study site — St Louis, Missouri, United States
• Study site — Albuquerque, New Mexico, United States
• Study site — Santa Fe, New Mexico, United States
• Study site — Armonk, New York, United States
• Study site — Columbus, Ohio, United States
• Study site — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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