Safety Study to Determine the Appropriate Dose of Antibody Against Tumor Cells to Best Target Patients With Pancreatic Cancer.
Stopped early · Early Phase 1
Conditions studied: Pancreatic Cancer
In brief
This no treatment research study is being done to find a safe and an appropriate dose of antibody (protein) against tumor cells to best target the cancer in people with pancreatic cancer. To do this, this no-treatment research study will compare two doses of an antibody called hPAM4 IgG when combined with a radioactive element, Indium-111.
Key facts
- Study ID
- NCT00364364
- Run by
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- People needed
- 2
- Starts
- 2007-05-01
- Expected to finish
- 2008-08-01
- Last updated by the study team
- 2019-01-18
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- A.Subjects with a significant concurrent medical complication that in the judgment of the Principal Investigator could affect the patient's ability to tolerate or complete this study. These include, but are not restricted to
- Known history of active coronary artery disease, unstable angina, myocardial infarction, or congestive heart failure present within 6 months or cardiac arrhythmia requiring anti-arrhythmia therapy.
- Known history of active COPD, or other moderate-to-severe respiratory illness present within 6 months.
- B. Subjects who have signs of intestinal obstruction.
- C. Subjects who are pregnant are excluded. D. Subjects who have a measurable antibody response to hPAM4 in their pre-study sample or who are proven allergic upon testing with the agent.
- E. Patients who are known to have HIV.
- F. Patients who have a known history of Hepatitis B or C or any other serious liver abnormality will be excluded from enrollment.
- G. Prisoners or other institutionalized persons.
Where it is running
- Johns Hopkins Institution, Dept of Radiology and Radiological Science — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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