Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD

Completed · Not applicable · Has a placebo group

Conditions studied: Obsessive-Compulsive Disorder

In brief

The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and that tolerance (loss of therapeutic effect) to the medication will not develop over a period of several weeks.

Key facts

Study ID

NCT00363298

Run by

Stanford University

People needed

24

Starts

2006-08-01

Expected to finish

2008-03-01

Last updated by the study team

2017-03-28

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• outpatient age 18 through 55 inclusive
• meets DSM-IV criteria for obsessive-compulsive disorder (OCD) with Yale-Brown Obsessive-Compulsive Scale (YBOCS) score greater than or equal to 20
• provides written informed consent
• has taken for at least 12 weeks at least the dose shown of a selective serotonin reuptake inhibitor (SSRI) [citalopram, escitalopram, or fluoxetine 20 mg/d; paroxetine 40 mg/d; sertraline 50 mg/d]; or venlafaxine 225 mg/d; or duloxetine 60 mg/d.
• if taking buspar, gabapentin, an atypical antipsychotic, or a benzodiazepine, dose has been stable for 4 weeks
• has negative urine drug and pregnancy tests
• is practicing reliable birth control method
• has blood pressure readings at screening visit that are less than 140 mm Hg systolic and 90 mm Hg diastolic,
• weight is greater than 100 lbs at screen

You may not qualify if…

• requires psychotropic medications other than an Serotonin Reuptake Inhibitor (SRI), a benzodiazepine, buspirone, an atypical antipsychotic, and/or gabapentin
• is taking clomipramine
• is taking fluvoxamine
• is taking medication that inhibits hepatic enzyme CYP1A2
• is taking a monoamine oxidase inhibitor
• has co-morbid tics or Tourette's disorder
• has hoarding as the primary or only OCD symptom
• has a history of panic disorder
• has a history of glaucoma
• has a history of seizures
• has a history of schizophrenia or psychotic disorder, or schizotypal personality disorder
• has depression with current suicide risk
• has mental retardation, pervasive developmental disorder, or cognitive disorder
• has a factitious disorder
• has current or past cyclothymic disorder or bipolar disorder
• has a dissociative disorder
• has personality disorder sufficient to interfere with study participation
• has organic mental disorder or dementia
• has current or past substance abuse / dependence (excluding nicotine)
• has current or past anorexia or bulimia
• has serious or unstable medical disorder, including hypertension or cardiac disease
• has history of myocardial infarction or cardiac arrhythmia
• has history of or has current diagnosis of hypertension
• is pregnant or breast-feeding
• is receiving psychotherapy for OCD

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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